Shimada School went wild, which completely dashed the idea of coexistence of human beings and parasitic animals. Quan Xinyi's life has undergone great changes, and he and Limei (Ai Hashimoto) seem to be estranged by this incident. On the other hand, Yoshiko Tamiya (Akira Kurotsu) gradually changes her mood after giving birth to a child, and she tries to integrate her companions into the human world in a peaceful way. But Dongfu Mayor Hirokawa Tsuyoshi (Kitamura Yoshihiro) instructs diehards in parasitic animals such as Goto (Tadashi Asano) to obliterate Shinichi and Xiaoyou (voiced by Takashi Abe) and freelance journalist Kang Mori (Nanpeng Omori), who tries to expose the existence of parasitic animals. The fighting between the two sides gradually escalated, the heavily armed police began to attack the city government of Hirokawa, and Shinichi and Liangzi will once again usher in the great test of life. This film is based on a classic cartoon with a cumulative circulation of more than 13 million copies.