Alice (Milla Jovovich) was replicated by the Umbrella Company laboratory and became a research specimen for Dr. Isaac (Ian Gray Iain Glen). Because the DNA in her body can fight against the T-virus, the doctor uses it to increase the lethality of zombies. Alice received a distress signal from humans, but fell into a trap and fought hard before saving herself. She was relieved, but in her sleep, she strongly felt the call of powerful power in her body. Obviously, the Umbrella Company laboratory had done something to her. Moreover, Dr. Isaac also injected human blood into the zombies to activate their human minds. The zombies become more powerful and cannot be controlled at all. They brutally kill laboratory assistants and are trained to deal with Alice. Three years later, the earth became barren. Survivors in Nevada formed an alliance, and Alice was among them, but she was afraid to reveal her identity because the laboratory gave her powers and forced her to be a spy. Alice was isolated, and only Carlos understood her difficulties, and the two fell into an ambiguous relationship...