The calm vacation of super cargo man Frank Martin (Jason Statham) is broken again when a man driving an Audi drives a girl on a rampage through Marseille, while businessman Robert Knepper is facing the country's environment minister to transport toxic substances to Ukraine. The injured Audi driver broke into Frank's home and died from a bomb on his wrist. His behind-the-scenes boss Johansen forced Frank to take over the task of transporting the girl. Frank, who was equipped with a bomb on his wrist, had to give in because as long as he left the car, the bomb would explode. On the way to Budapest, Frank finally understood the truth of the mission: the girl Valentina (Natalya Rudakova) was the daughter of the Minister of Environment of Ukraine. Johansen kidnapped Valentina to get the Minister to approve his plan. In the pursuit of Johansen and the Minister, how should Frank resolve this crisis?