Grace Hospital in Seattle welcomes a new batch of interns, Meredith Gray (Ellen Pompeo), Christina Young (Wu Sandra Sandra Oh), Isobel Steven (Catherine Heigl Katherine Heigl), George Merry (T.R. Knight T.R. Knight), Alex Carey (Justin Chambers Justin Chambers), five medical school friends graduated at the same time. It is necessary to compete for the official seat of resident with good performance. As soon as she entered the hospital, Meredith was devastated to find that the man who had an one-night stand with her in the bar the night before was neurosurgeon Derek Sherber (Patrick Demsey Patrick Dempsey), and the entanglement began; Christina attracted the attention of chest surgeon Preston Burke because they were equally arrogant and ambitious; George quietly loved Meredith. The beautiful Isobel immediately set off rumors that the one-year internship was destined to be full of high-density pressure competition and hormones.
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