The story of the Crazy takes place in an era similar to the real world, when Anne Lanzbo (Emma Stone) and Irving Milgrim (Jonah Hill) are strangers for different reasons. attracted by a late trial of a mysterious drug. Annie was disgruntled and didn't know where to go, but she couldn't let go of the broken relationship between her mother and sister. Owen, the fifth son of a wealthy entrepreneur in New York, was diagnosed with suspected schizophrenia and had been living a miserable life. Both lives are not going well. Dr. James K. Mantrelle (Justin Theroux) has invented a series of pills and launched extreme new drug treatments that claim to repair a variety of mental disorders, including mental illness and extreme sadness. This attracted the two men and ten other strangers to join Neberdine Pharmaceutical Biotechnology (Neberdine Pharmaceutical and Biotech) for a three-day drug trial. The trial promised that the subjects would not have complications or any side effects and could eradicate all their problems. But often, things don't go according to plan.