Based on Armistead Maupin's series of novels of the same name, Mary returns to San Francisco after 20 years of abandoning his husband and daughter to pursue a career and is reunited with his daughter and ex-husband Boo Brian (played by Paul Gross). Escaping the midlife crisis caused by a seemingly perfect life in Connecticut, Mary Ann was soon pulled back into the life of Anna, her chosen family, and a new generation of strange young residents at 28 Barberly Lane.