The film focuses on the first day of the "silent apocalypse". Human beings have not yet mastered the law of "death if they speak" and are vulnerable to monsters. Thousands of monsters fell from the sky, reaching the largest number in the series. The perspective has also been upgraded from the rural town of the previous game to New York, the largest city in the United States. The world has fallen, and the streets, subways, supermarkets and other places where human lives have become Critically dangerous. Once there is a sound, it will be "enlarged" by hidden monsters. The noisy New York has fallen into a silent and isolated city, where surviving humans staged an extreme escape.