In 1959, the guerrilla organization led by Che Guevara (Benicio Del Toro Benicio del Toro) and Fidel Castro (Rodrigo Santoro Rodrigo Santoro) finally overthrew the Batista regime and established a new government in Cuba. However, with the passage of time, Che and Fidel gradually disagreed on the concept of governing the country, and finally he resigned from an important position in the government, gave up his family and Cuban citizenship, and once again joined the war to liberate the third World. After several twists and turns, Che came to Bolivia to launch a guerrilla revolutionary movement with the Bolivian National people's Liberation Army. Bolivian President Ren é Barrientos (Joaquim de Almeida) learns that Che is coming and decides to destroy this troublesome revolutionary at all costs. In order to recreate the revolutionary years of the revolutionary Che Guevara in detail, the famous Hollywood director Steven Soderbergh spent four hours depicting the legendary hero. Finally, according to the needs of the cinema, the film was divided.