The film, directed by Walter Baker, director of Mouse Noble 4: cute, is adapted from the best-selling children's book Clifford the Big Red Dog of the same name. It tells the story of a little girl named Emily Elizabeth (Darby Camp) who gets a puppy in New York. The red dog named Clifford is cute and becomes her best friend who is unsociable and lonely at school. But the dog grew into a behemoth and was attracted by a biological genetics company, and Emily and uncle Casy (Jack Whitehall) had to take him away from the greedy people.