After a change, Gru (Steve Carell Steve Carell) made great achievements as an agent, but was kicked out by the new director for failing to beat the bad boy Bassazar Brad (Tripak Trey Parker). Just then, he received a letter from afar and learned that he had a twin brother Drew (voiced by Steve Carrell Steve Carell). At Drew's kind invitation, Gru took his wife Lucy Wilde (voiced by Kristen Weiger Kristen Wiig) and Margo (voiced by Miranda Cosgrove Miranda Cosgrove), Edith (voiced by Dana Gay Dana Gaier) and Agrace (voiced by Elsie Fisher Elsie Fisher) to visit relatives at the place where his biological father lived. Drew is naive, but he wants to partner with his brother to become a villain duo. Although Gru temporarily returned to the wild, but the heart of justice has not been extinguished. Especially when Bassazar's evil plan was involved with three lovely children, he could no longer sit back and watch.