Jess (Ashton Kutcher Ashton Kutcher) and Chester (Sean William Scott Seann William Scott) wake up from an one-night hangover, they find strangers and pudding hills in their home, and their twin girlfriend's house is also messed up by them. to make up for their complete amnesia last night, they hurried out to pick up the pieces and rushed to their girlfriend's house to celebrate the first anniversary of dating. However, when they went out, they found that the car was gone. Jess and Chester's car-hunting experience is an adventure. Strange people and phenomena emerge one after another, such as dogs smoking marijuana, transgender people who claim 200000 dollars from them, mysterious gangs that believe in alien conspiracies, cars involved in drug trafficking and the Hot Girls five. Apparently, Jess and Chester created an extraordinary story when they were drunk.