Two couples-Matt (Leigh Whannell) and Nina (Mirrah Foulkes), Jack (Nathan Phillips) and Rebecca (Melanie Vallejo) come to Tasmania, Australia. Between the 18th and 19th centuries, it was a small island used by the British Empire to exile prisoners. The island was too harsh to escape, except for an Irish man named Alexander Pierce (Peter Docker). Nina's sister came here to look for the long-extinct Tasmanian tiger, but she died mysteriously in the end. Eight years later, Nina, who was also studying biology, came here to fulfill her sister's unfinished wish and try to solve the mystery of her sister's death.