Led by Duke (Channing Tatum), special forces dealt a heavy blow to the terrorist organization Cobra. Although the Cobra Commander and other central figures were arrested, the White Ghost (Li Bingxian) and other organizational backbones are still at large, ready to launch a counterattack against the special forces and the world. After a clean and tidy resolution of the nuclear crisis in a Middle Eastern country, the special forces suddenly suffered a tragic blow from the U.S. government. The Duke and other members died heroically, but only three people in the way (Dwayne Johnson), Miss Jay (Adrianne Palicki) and Flynn (D.J. Cotrona D.J. Cotrona) narrowly escaped. It turned out that cobra had long penetrated into the top echelons of the United States, and they used it to discredit the special forces and frame the snake's eye of one of the important members. The purpose was to find and rescue the imprisoned commander. The three Obstacles, who are nominally "dead", must do everything possible to stop the Cobra's evil plan and correct their dead comrades and special forces...