This film is a sequel to the 10th anniversary of "The Silence of the Lambs", an episode still adapted from a novel by writer Thomas Harris. Hannibal (Anthony Hopkins), who escapes from a high-security hospital, continues to find his "prey", only to become the target of Mason (Gary Oldman), who narrowly survived his own knife. Mason is a heinous pedophile. He once raped his own sister, escaped from prison when he was young, and received psychological treatment from the demon Hannibal Lecter. However, Hannibal Lecter caused him to be partially paralyzed and severely disfigured. He now has to rely on artificial respirator to survive. But he had a huge fortune and constantly collected various children, hoping to lure Hannibal out for horrific retaliation. In desperation, Hannibal turns to Agent Clarice (Julianne Moore) for help. In a duel between two demons, who will win and who will lose?