The young woman Lucy (Scarlett Johansson), who is forced by her evil boyfriend to help deliver goods, meets the gang of the extremely vicious gang leader Mr. Zhang (Cui Minzhi). She and three men were sewn into the mysterious drug codenamed CPH4 by Mr. Zhang in order to secretly bring the drug into different countries. While in Taipei, Lucy was beaten by a vicious man, causing the medicine to rupture and enter her blood. Unexpectedly, something unbelievable happened. The drug stimulated the potential of Lucy's brain, awakening about 90% of the neurons in the human brain. With the rapid evolution of her body, Lucy mastered more and more so-called super powers. She clearly understood the powerful power of CPH4, so she tried every means to prevent the other three bags of drugs from falling into the hands of Mr. Zhang and his gang. During this period, she tried to get in touch with Samuel Norman (Morgan Freeman), a senior professor of brain research. Under the latter's witness, Lucy will usher in a historic moment when her brain is 100% awake...