Due to his outstanding performance as a guard at the Museum of Natural History in New York, Larry (Ben Stiller) became the CEO of a small home appliance company and was interviewed by a famous talk show host on TV. His son admired him, and his love followed him like a shadow, looking triumphant. However, the good times did not last long. When he revisited the old place, he unexpectedly discovered that the director had already updated the exhibition and was preparing to move the outdated exhibits to the Smithsonian Museum in Washington to continue displaying them. This made Larry feel a little angry. He felt that he had a responsibility to restore the museum, so he decided to stay and work as a guard for another night to arouse the joint efforts of his old friends. In fact, after dealing with Roosevelt (Robin Williams), Lincoln, Napoleon, Ivan the Great and Al Cabon, he encountered a strong enemy-Kamra, the evil ancient Egyptian pharaoh. The two staged another thrilling showdown at the museum at night...