Frank (Bill Murray Bill Murray) is an ordinary zoo keeper. One day, he eats an apple eaten by a monkey, and a virus named Rex (voiced by Lawrence Fishburne Laurence Fishburne) arrives inside Frank. Also here, there is a white blood cell named Oz (voiced by Chris Locke Chris Rock), which is a maverick white blood cell, which is not satisfied with mediocre daily life, but wants to live a wonderful life and new ideas. Oz's nemesis is a cold pill named Drax (David Hyde Pierce David Hyde Pierce), which exists to restrain the unruly Oz, and the relationship between the two is very tense. However, when Rex appeared in front of them, everything changed, and Oz and Drax had to join hands to protect Frank's health from damage.