Richard (Paul Giamatti) and Rachel (Catherine Hahn) suffer from infertility. The couple devoted themselves to assisted fertility and adoption arrangements, getting deeper and deeper in this narrow field, while making efforts to maintain their marriage. They tried IVF, and their emotions and finances were seriously affected. When middle age was coming to an end, Sadie (Kelly Carter), who had just dropped out of college, appeared and re-entered their lives. Everything is finally starting to get better.