Recently, there has been a serial murder case by murderers. The most disgusting thing is that the murderers slit the victim's throat after each crime. FBI agent Will (Edward Norton) is responsible for the investigation of the case. After detailed investigation, Will analyzed that this person would cut the victim's throat and eat it every time, but he could not find any traces of the murderer. Will turns to the mentally ill criminal psychologist Hannibal (Anthony Hopkins) for help, hoping that Hannibal can portray the murderer's criminal psychology to help solve the case. Unexpectedly, Hannibal suffered a mental illness, intended to harm Will, and was finally put in a mental prison, and the case was settled. Years later, Will encountered the same murder case again. Although the criminal suspect was identified, Will had to find Hannibal again if he wanted to clearly understand the criminal psychology of this person and use it to justice.