Peter Parker (Tobey Maguire) is just an ordinary high school student in the United States. When he was bitten by a mutant spider that sneaked out of the Spider Museum, Peter's life changed completely. He became like a spider, with various special powers unique to spiders: spraying extremely sticky spider silk from his fingers, flying over roofs and walls, etc. Peter was very excited and began to use his super powers to make money. But when his favorite uncle was killed by a criminal he had let go, Peter vowed to use his powers to fight crime. Peter's friend Harry's father, Norman (William Dafoe Willem Dafoe), is the owner of a biotechnology company and is distressed that the aircraft produced by his company have not been appreciated by military leaders. Norman accidentally inhaled nerve gas and developed super powers, triggering his evil nature and riding his own aircraft to destroy and kill people everywhere. Peter's Spider-Man is starting to attack!