In the vast and peaceful primeval forest, the happy Smurfs are preparing for the annual Blue Moon Festival. At this joyous and busy moment, their old enemies, the evil wizard Gargamel (Hank Azaria Hank Azaria) and his pet Azrael, invade the Smurfs' secret territory. The frightened Smurfs fled, and poor Benben (voiced by Anton Eugene Anton Yelchin) ran blindly into the waterfall where 99 Smurfs were said to have died. Finally, Benben, together with his rescuers Blue Dad, Smurfette and Congcong, were involved in a mysterious whirlpool and came to the Central Garden in New York, USA. In this completely unfamiliar world, they are helped by Patrick (voiced by Neil Patrick Harris Neil Patrick Harris) of the cosmetics industry. In order to return to the great forest, the Smurfs tried every means. At the same time, Gargamel and Aziz also came to New York. This film is based on a cartoon co-created by Belgian cartoonist Peyo and his wife, and was introduced into the TV version of animation by the United States in the early years.