Shi Yu (Gong You), the fund manager of a securities company, is handsome and capable, but he is also a person who values profit over righteousness. His wife breaks with him over this, and her daughter Xiu 'an (Kim Xiu' an) becomes increasingly disappointed with such a selfish father and decides to go to Busan to live with her mother. On Xiu 'an's birthday, Shi Yu took time out to accompany his daughter on the express train to Busan. At the same time, extremely suspicious riots broke out all over the city. The government's efforts to whitewash cannot cover up the fact that zombies are rampant. Even ignorant train passengers have fallen into a hell of panic and despair because of the arrival of uninvited guests. At the moment of driving, an infected person rushed into the carriage, and she quickly transformed and carried out a bloody massacre of healthy people everywhere she could see. Not long after, the number of zombies exploded exponentially. Shi Yu was forced to fight hard to survive in the cramped space with the passengers of the survivors. The distant journey to Busan is full of killing intent, and the humanity of every survivor in times of crisis is also subject to a huge test...