Harry (Jared Leto) and Marianne (Jennifer Connelly) love each other, dream of opening a clothing store, and dream of a better tomorrow. However, they are all inseparable from drugs and want to make their first pot of gold by selling drugs. Harry's mother is a complete TV fan. Her biggest dream is to be on TV, and she eats diet pills regardless of her age. She gradually became addicted because of the drug content in the medicine. Harry's friend Dillon (Marlon Wayans) is also an addict who joins the underworld in order to make a lot of money. For their dreams, they work hard, but they are gradually trapped in drugs. Harry's arm was cut off due to an injection drug infection; Marianne sold her body and self-esteem for drugs; Harry's mother was eventually admitted to a mental hospital and tortured; Dillon was imprisoned. When the vision becomes blurred and dreams call from afar, what attitude should the lost person take to comfort his soul?