In the desert of Syria, female vampire Danica (Parker Posey) leads a team of her kind deep into the ancient desert palace, hoping to awaken the sleeping king of vampires-Drake (Dominic Purcell). In the night, Blade (Wesley Snipes) is still engaged in endless battles with vampires, but he quickly falls into Danica's trap and mistakenly kills a human, so he is arrested by FBI agent Wilson and others. At the same time, Blade's old partner Abigail (Jessica Biel), daughter of Whistler, and Hannibal King (Ryan Reynolds) and other young people hold beliefs similar to Blade's and form a team that uses themselves as bait to eliminate vampires. They rescue Blade from the FBI and Danica, but the latter scoffed at their boldness. However, facing the powerful vampire king Drake, they had to fight side by side...