The plot of this film follows the original film, which narrates that before Stitch, "experiment 626", Dr. Qiang Ba had hundreds of failed experiments, and now he has secretly smuggled all these experimental products to the earth. The unscrupulous escaped hamster flywheel and Captain Gantu, who was dismissed and held a grudge, kidnapped Dr. Qiang Ba, and went to find the previous 625 experiments to create a new little magic star again. These bizarre interstellar baby experiments include experiment 221, which emits powerful airwaves, and experiment 625, which is lazy but can make delicious sandwiches. Now, Hawaiian seven-year-old girl Lilo (Lilo) and interstellar baby Stitch (Stitch) want to help the Star Alliance do a carpet search in the Hawaiian islands, find 625 experiments ahead of the bad guys, and help these interstellar babies find their own warm homes!