Agent Stratton (Dominic Cooper Dominic Cooper)'s colleague Marty (Taylor Hodglin Tyler Hoechlin) was killed on a mission. Stratton learns that a defected former Soviet agent Barofsky (Thomas Clay Schumann Thomas Kretschmann) has a number of extremely dangerous biological weapons, and now he is trying to use them to realize his revenge plan. Stratton came to Rome to stop Barofsky's plot. Hank (Austin Stovier Austin Stowell) is Marty's best friend and a member of the action team, hatred goes to his head, his mistake leads to the failure of the whole action plan, and Barowski escapes from under their noses. The party had to go back to London and replan, leaving them little time.