The film is a live-action and CGI R-rated comedy about abandoned puppy Reggie and other stray dogs teaming up to get back at their former owner. It is said that dogs are man's best friends, but what if a dog owner is a big asshole? If that's the case, it's time for the Vengeance Dog Alliance to assemble. Reggie (voiced by will Farrell) is an innocent, optimistic border dog. Although he is abandoned on the cruel streets of a big city by his scum male owner Doug (will Ford), Reggie still believes that his favorite owner will never abandon him on purpose. But when Reggie meets a Boston poodle bug (Jamie Fox), a freedom-loving stray who believes that only a stupid dog needs a master, Reggie finally finds out that his owner, Doug, has been abusing him all the time, and Doug is a heartless scum. In order to avenge the wolf-hearted dog owner, Reggie, Bug and Bug's Maggie (voiced by Ella Fischer), an ice-smart Australian shepherd dog, but its owner snubbed him because he adopted another puppy; and Hunter (Lan.