An unexpected incident in his childhood separated Peter Parker (Andrew Garfield) from his parents. In the blink of an eye, Peter becomes a high school student. He accidentally finds his father's briefcase and gets clues from his uncle Ben (Martin Sheen), so he sets off to Osko Company to visit his father's partner at the time, Kurt Connors.(Rhys Ifans). Peter, who was searching for clues in the company, was accidentally bitten by a spider. On the way back, his body underwent strange changes. Under the guidance of Dr. Connors, Peter continued to understand and discover the extraordinary abilities in his body. All kinds of unexpected things quickly came to him. Until one day, he became a far-reaching super soldier Spider-Man. And fierce lizard-men also appeared in the city, and Peter's extraordinary life began...