Ronnie (Vince Vaughn Vince Vaughn) and Nick (Kevin James Kevin James) are very close friends, accompanying them all the way into the workplace from their college days, they seem to know each other most well in the world. Not only that, Ronnie's girlfriend Beth (Jennifer Connery Jennifer Connelly) and Nick's wife Genova (Winona Reed Winona Ryder) are also good friends who talk about everything. The story starts from the day Ronnie ran into Geniwa in the street. The fatal thing is that it was not her husband, Ronnie's good friend Nick, but another handsome man he didn't know who stood close to her on that day. This matter has become Ronnie's heart knot, in front of friendship and morality, Ronnie does not know how to choose. Even more shocking to Ronnie, he gradually discovered that Nick had secrets that he could not tell him.