Doug (Justin Bartha) is about to marry his girlfriend. Two days before the wedding, Doug and his friends Phil (Bradley Cooper), Sid (Ed Helms) and Alan (Zach Galifianakis) drove from Los Angeles to Las Vegas to host a bachelorette party for Doug and checked into the Caesar Palace Luxury Suite. One night later, the three found Doug missing, a tiger appeared in the bathroom, a baby appeared in the closet, Sid had a missing tooth, a Simmons mattress on the spire outside the window, and Phil was wearing a hospital bracelet. Sid had a receipt for $800 in his pocket, and their car somehow turned into a police car. The three were panicked and completely unable to remember what had happened last night, but they had to quickly solve the mystery within 24 hours to find Doug and return to Los Angeles...
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