Finally one day, mankind declared war on the increasing number of blood clans and wolves. These two groups were extensively besieged and slaughtered, and mankind gained an absolute advantage. Selina (Kate Beckinsale) and John also suffer in this catastrophe. When she wakes up again, she finds herself imprisoned by an institution called the Antigen Institute, numbered Subject 1. She struggled to break through the shackles and searched for the experimental subject No. 2, John, in the dark city based on her ability to see together. On the way, she encountered the help of her blood kin companions and attacked by werewolves. When she found Experimental Subject No. 2, which was being chased by the werewolves, she found that she was a little girl who she had never met but had extremely terrifying powers-Evie (India Eisley), and she was a hybrid of blood kin and wolf. In this unfamiliar era, Selina is destined to continue to live a bloody life...