Dr. Doolittle (Eddie Murphy Eddie Murphy) has a happy family and a well-known clinic, and no one knows that he has an unusual experience of being able to understand animals. When he was young, he talked to animals such as cats, dogs, horses and donkeys to understand their needs and what was on their minds. As he grows older, Dr. Doolittle has long lost this "special power." However, he almost hit a puppy on the side of the road because he was driving a car, and he seemed to hear the puppy call him stupid again. Now Doolittle's life became lively, because his long-sleeping talent for animal language was reawakened, and the cat and dog not only became his friend, but also took the initiative to come to see Dr. Doolittle. The clinic has become a bustling animal world, and business is in the doldrums as a result. Everyone thought Doolittle was crazy, and his family didn't understand his behavior. Dr. Doolittle and his clinic faced a lot of challenges.