Sanford (John Cusack John Cusack) is a psychiatrist who cures other people's diseases while Sanford's own family is scarred. Son Benji (Evan Byrd Evan Bird) is locked up in rehab for taking drugs at a young age, while daughter Agatha (Mia Wasikovska Mia Wasikowska) is even worse when she is locked up in a mental hospital for arson. Not only is her family life in trouble, but Sanford's career is also at a bottleneck. Havana (Julianne Moore Julianne Moore) is a patient and an actress who lives in the shadow of her mother, who is also a famous actress, and even her dreams are haunted by her mother's phantom. Agatha was discharged, Benji returned to the family, and the return of the children brought more trouble and chaos to Sanford.